| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 18 de Febrero | |||
| Cavaly | - | New England Revolution | 16:30 |
| Emelec | 4 - 0 | Macara | 18:00 |
| Agropecuario | 0 - 1 | Estudiantes de Rio Cuarto | 14:00 |
| Instituto Cordoba | 0 - 0 | Alvarado | 16:15 |
| Defensores De Belgrano | 0 - 2 | Temperley | 18:30 |
| OHiggins | 1 - 1 | Huachipato | 15:00 |
| 12 de Octubre | 2 - 1 | Sportivo Ameliano | 15:15 |
| Cerro Largo | 0 - 5 | Plaza Colonia | 17:00 |
| Resistencia | 3 - 1 | Nacional Asuncion | 17:30 |
| Union Espanola | 1 - 1 | Everton de Vina | 17:30 |
| Deportivo Pasto | 2 - 0 | Deportivo Cali | 17:10 |
| Fluminense | 3 - 0 | Volta Redonda | 16:00 |
| Durango | 1 - 1 | Mazorqueros | 20:00 |
| Dynamo Dresden | 1 - 1 | FC Heidenheim | 11:30 |
| FC Schalke 04 | 2 - 0 | SC Paderborn 07 | 11:30 |
| FSV Mainz 05 | 3 - 2 | Bayer Leverkusen | 13:30 |
| Boavista | 2 - 2 | Benfica | 14:15 |
| Lille | 0 - 0 | Metz | 14:00 |
| Elche | 2 - 1 | Rayo Vallecano | 14:00 |
| Juventus | 1 - 1 | Torino | 13:45 |
| Puebla | 1 - 0 | Monterrey | 19:00 |
| FC Juarez | 0 - 0 | Santos Laguna | 21:00 |
| Club Tijuana | 1 - 1 | Necaxa | 21:06 |
| FC Cartagena | 2 - 3 | Valladolid | 14:00 |
| Monarcas | 4 - 1 | Cancún | 17:00 |
