| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 21 de Enero | |||
| Moldova | 4 - 0 | South Korea | 05:00 |
| Bolivia | 5 - 0 | Trinidad and Tobago | 15:00 |
| Santa Fe | 1 - 1 | La Equidad | 17:00 |
| Deportivo Pasto | 0 - 1 | Millonarios | 19:05 |
| Iraq | 1 - 0 | Uganda | 09:00 |
| Wanderers | 0 - 0 | Rentistas | 18:00 |
| Durango | 3 - 1 | Atlético Saltillo | 20:00 |
| Arouca | 0 - 2 | Benfica | 13:00 |
| Paços de Ferreira | 1 - 1 | Boavista | 15:15 |
| Hamburger SV | 2 - 1 | FC St. Pauli | 11:30 |
| Eintracht Frankfurt | 0 - 2 | Arminia Bielefeld | 13:30 |
| Parma | 0 - 1 | Frosinone | 13:30 |
| Espanyol | 1 - 4 | Real Betis | 14:00 |
| Lyon | 1 - 0 | Saint Etienne | 14:00 |
| De Graafschap | 1 - 0 | Almere City FC | 13:00 |
| Den Bosch | 0 - 2 | FC Eindhoven | 13:00 |
| Jong AZ | 2 - 0 | VVV Venlo | 13:00 |
| Roda | 5 - 0 | ADO Den Haag | 13:00 |
| Jong PSV | 3 - 0 | Excelsior | 13:00 |
| MVV | 0 - 1 | FC Volendam | 13:00 |
| Verona | 2 - 1 | Bologna | 13:45 |
| Watford | 0 - 3 | Norwich | 14:00 |
| Mazatlán | 1 - 2 | Toluca | 21:00 |
