| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 19 de Enero | |||
| Hannover 96 | 3 - 0 | Borussia Monchengladbach | 11:30 |
| RB Leipzig | 2 - 0 | Hansa Rostock | 11:30 |
| Egypt | 1 - 0 | Sudan | 13:00 |
| Guinea-Bissau | 0 - 2 | Nigeria | 13:00 |
| 1899 Hoffenheim | 1 - 4 | SC Freiburg | 13:45 |
| Hertha Berlin | 2 - 3 | Union Berlin | 13:45 |
| Sassuolo | 1 - 0 | Cagliari | 10:30 |
| Inter | 3 - 2 | Empoli | 14:00 |
| Groningen | 1 - 2 | NEC Nijmegen | 11:45 |
| NAC Breda | 2 - 1 | PEC Zwolle | 13:00 |
| Real Sociedad | 2 - 0 | Atletico Madrid | 14:00 |
| Twente | 1 - 2 | AZ Alkmaar | 14:00 |
| Leicester | 2 - 3 | Tottenham | 13:30 |
| Brentford | 1 - 3 | Manchester United | 14:00 |
| Clermont Foot | 0 - 2 | Strasbourg | 12:00 |
| Toulouse | 4 - 0 | Nancy | 12:00 |
| Montpellier | 0 - 1 | Estac Troyes | 12:00 |
| Lille | 3 - 1 | Lorient | 12:00 |
| Celta Vigo | 2 - 0 | Osasuna | 12:00 |
| Valencia | 1 - 1 | Sevilla | 14:30 |
| Santos Laguna W | 1 - 1 | Necaxa W | 19:00 |
| Leon | 1 - 1 | Atlas | 21:00 |
| Celaya | 1 - 1 | Atlante FC | 17:00 |
| Pumas Tabasco | 2 - 0 | Tampico Madero | 19:05 |
| Alebrijes de Oaxaca | 1 - 1 | Leones Negros UDG | 21:05 |
