| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 14 de Enero | |||
| Senegal | 0 - 0 | Guinea | 07:00 |
| Morocco | 2 - 0 | Comoros | 10:00 |
| Malawi | 2 - 1 | Zimbabwe | 10:00 |
| Gabon | 1 - 1 | Ghana | 13:00 |
| FBC Melgar | 1 - 0 | Deportivo Pereira | 18:00 |
| OHiggins | 1 - 0 | Deportes Santa Cruz | 18:00 |
| Wanderers | 0 - 1 | Boston River | 18:00 |
| Liverpool | 1 - 1 | Rentistas | 18:00 |
| Alianza Lima | 3 - 2 | La Equidad | 19:00 |
| Real Unión | 0 - 1 | Eibar | 04:00 |
| Dynamo Dresden | 1 - 1 | Hamburger SV | 11:30 |
| PEC Zwolle | 2 - 0 | Willem II | 13:00 |
| Borussia Dortmund | 5 - 1 | SC Freiburg | 13:30 |
| Nice | 2 - 1 | Nantes | 14:00 |
| FC Eindhoven | 4 - 0 | Jong Utrecht | 13:00 |
| Almere City FC | 0 - 4 | Roda | 13:00 |
| VVV Venlo | 1 - 4 | Jong PSV | 13:00 |
| Telstar | 2 - 1 | MVV | 13:00 |
| NAC Breda | 0 - 0 | FC Volendam | 13:00 |
| Excelsior | 0 - 0 | De Graafschap | 13:00 |
| Brighton | 1 - 1 | Crystal Palace | 14:00 |
| Club Queretaro | 1 - 3 | U.N.A.M. - Pumas | 19:00 |
| Necaxa | 0 - 4 | Monterrey | 21:00 |
