| Miércoles 22 de Diciembre |
| Liverpool | 3 - 3 | Leicester | 13:45 |
| Brentford | 0 - 2 | Chelsea | 13:45 |
| Tottenham | 2 - 1 | West Ham | 13:45 |
| Casa Pia | 1 - 2 | Sporting CP | 14:45 |
| Singapore | 1 - 1 | Indonesia | 06:30 |
| Granada CF | 2 - 1 | Atletico Madrid | 12:00 |
| Heerenveen | 0 - 3 | Feyenoord | 11:45 |
| Willem II | 0 - 1 | NEC Nijmegen | 11:45 |
| Heracles | 1 - 1 | Cambuur | 13:00 |
| Ajax | 5 - 0 | Fortuna Sittard | 14:00 |
| Utrecht | 1 - 1 | Twente | 14:00 |
| Venezia | 1 - 3 | Lazio | 09:30 |
| Sassuolo | 0 - 3 | Bologna | 09:30 |
| Verona | 1 - 1 | Fiorentina | 11:30 |
| AS Roma | 1 - 1 | Sampdoria | 11:30 |
| Inter | 1 - 0 | Torino | 11:30 |
| Empoli | 2 - 4 | AC Milan | 13:45 |
| Napoli | 0 - 1 | Spezia | 13:45 |
| Monaco | 2 - 1 | Rennes | 14:00 |
| Marseille | 1 - 1 | Reims | 14:00 |
| Lyon | 1 - 1 | Metz | 14:00 |
| Lorient | 1 - 1 | Paris Saint Germain | 14:00 |
| Estac Troyes | 1 - 1 | Stade Brestois 29 | 14:00 |
| Bordeaux | 2 - 3 | Lille | 14:00 |
| Saint Etienne | 0 - 1 | Nantes | 14:00 |
| Nice | 2 - 1 | Lens | 14:00 |
| Montpellier | 4 - 1 | Angers | 14:00 |
| Athletic Club | 1 - 2 | Real Madrid | 14:30 |
| Barracas Central | 0 - 0 | Quilmes | 17:10 |
| Deportes Tolima | 1 - 2 | Deportivo Cali | 18:30 |
