| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 17 de Noviembre | |||
| ADT | 2 - 1 | Maristas | 14:30 |
| Celaya | 3 - 1 | Cancún | 17:00 |
| Venados FC | 3 - 0 | Tapatío | 19:05 |
| Cimarrones | 0 - 1 | Correcaminos Uat | 21:05 |
| Villa Teresa | 0 - 0 | Racing Montevideo | 14:15 |
| Danubio | 0 - 0 | Cerro | 19:15 |
| Cuiaba | 1 - 0 | Internacional | 16:00 |
| America Mineiro | 0 - 0 | Atletico Goianiense | 16:00 |
| Santos | 2 - 0 | Chapecoense-sc | 16:00 |
| Fortaleza EC | 0 - 4 | Ceara | 17:00 |
| Juventude | 1 - 0 | Fluminense | 17:30 |
| Palmeiras | 0 - 2 | Sao Paulo | 17:30 |
| Flamengo | 1 - 0 | Corinthians | 18:30 |
| Bogota FC | 2 - 1 | Union Magdalena | 17:00 |
| Junior | 1 - 0 | La Equidad | 19:05 |
