| Miércoles 03 de Noviembre |
| Toronto FC | 2 - 1 | Pacific FC | 17:30 |
| Libertad | 2 - 0 | Sportivo Luqueno | 14:45 |
| Atlético Tembetary | 1 - 1 | Tacuary | 17:15 |
| Pachuca | 0 - 0 | Atletico San Luis | 19:00 |
| UD Parachique | 3 - 4 | ADT | 12:00 |
| Boca Juniors | 1 - 0 | Argentinos JRS | 18:10 |
| AC Milan | 1 - 1 | FC Porto | 11:45 |
| Real Madrid | 2 - 1 | Shakhtar Donetsk | 11:45 |
| Sheriff | 1 - 3 | Inter | 14:00 |
| Sporting CP | 4 - 0 | Besiktas | 14:00 |
| Borussia Dortmund | 1 - 3 | Ajax | 14:00 |
| Liverpool | 2 - 0 | Atletico Madrid | 14:00 |
| RB Leipzig | 2 - 2 | Paris Saint Germain | 14:00 |
| Manchester City | 4 - 1 | Club Brugge KV | 14:00 |
| River Plate | 0 - 1 | Wanderers | 06:45 |
| Liverpool | 0 - 1 | Rentistas | 13:30 |
| Nacional | 2 - 0 | Torque | 18:00 |
| Cruz Azul | 0 - 1 | Leon | 21:00 |
| Amorebieta | 4 - 1 | Valladolid | 12:00 |
| Eibar | 1 - 0 | Oviedo | 14:15 |
| Alebrijes de Oaxaca | 2 - 1 | Correcaminos Uat | 17:00 |
| Venados FC | 0 - 1 | Leones Negros UDG | 19:05 |
| Tampico Madero | 1 - 1 | Monarcas | 21:05 |
| Bournemouth | 1 - 2 | Preston | 13:45 |
| Blackburn | 0 - 7 | Fulham | 13:45 |
| West Brom | 1 - 0 | Hull City | 14:00 |
| Atletico-MG | 2 - 1 | Gremio | 18:00 |
| D. Melipilla | 2 - 1 | Cobresal | 13:00 |
| Huachipato | 1 - 0 | Union Espanola | 15:30 |
| Curico Unido | 0 - 2 | OHiggins | 18:00 |
| Coritiba | 3 - 1 | Operario-PR | 15:30 |
| Botafogo | 1 - 0 | Confiança | 16:00 |
| Montreal Impact | 2 - 0 | Houston Dynamo | 17:30 |
| New York Red Bulls | 0 - 0 | Atlanta United FC | 17:30 |
| Austin | 3 - 1 | Sporting Kansas City | 19:00 |
| Real Salt Lake | 1 - 3 | Portland Timbers | 20:30 |
