| Local | Visita | Hora | |
|---|---|---|---|
| Martes 26 de Octubre | |||
| 1899 Hoffenheim | 5 - 1 | Holstein Kiel | 11:30 |
| TSV 1860 Munich | 1 - 0 | FC Schalke 04 | 11:30 |
| SV Babelsberg 03 | 0 - 1 | RB Leipzig | 11:30 |
| Preussen Munster | 1 - 3 | Hertha Berlin | 11:30 |
| Borussia Dortmund | 2 - 0 | FC Ingolstadt 04 | 13:00 |
| VfL Osnabruck | 2 - 2 | SC Freiburg | 13:45 |
| FSV Mainz 05 | 3 - 2 | Arminia Bielefeld | 13:45 |
| SteDoCo | 0 - 5 | Utrecht | 11:45 |
| Roda | 2 - 1 | Den Bosch | 13:00 |
| PEC Zwolle | 4 - 1 | De Graafschap | 13:00 |
| ASWH | 1 - 3 | Heracles | 13:00 |
| Sparta Nijkerk | 0 - 2 | ADO Den Haag | 13:00 |
| FC Volendam | 0 - 3 | Emmen | 13:00 |
| NAC Breda | 1 - 1 | VVV Venlo | 14:00 |
| Arsenal | 2 - 0 | Leeds | 13:45 |
| Chelsea | 1 - 1 | Southampton | 13:45 |
| Venezia | 1 - 2 | Salernitana | 11:30 |
| Spezia | 1 - 1 | Genoa | 11:30 |
| AC Milan | 1 - 0 | Torino | 13:45 |
| Alaves | 1 - 0 | Elche | 12:00 |
| Espanyol | 1 - 1 | Athletic Club | 14:00 |
| Villarreal | 3 - 3 | Cadiz | 14:30 |
| Alebrijes de Oaxaca | 0 - 0 | Atlante FC | 17:00 |
| Mineros de Zacatecas | 3 - 1 | Celaya | 19:05 |
| Cancún | 2 - 2 | Cimarrones | 21:05 |
| Los Angeles FC | 3 - 0 | Seattle Sounders | 21:30 |
