| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 13 de Octubre | |||
| Tacuary | 0 - 0 | Sportivo Iteno | 14:00 |
| Colegio Comercio | 1 - 2 | ADT | 19:00 |
| Maristas | 0 - 0 | Cusco | 19:00 |
| Bangladesh | 1 - 1 | Nepal | 06:00 |
| India | 3 - 1 | Maldives | 11:00 |
| Argentinos JRS | 2 - 1 | San Telmo | 19:10 |
| Durango | 1 - 0 | Gavilanes FC Matamoros | 20:00 |
| Mineros de Zacatecas | 0 - 1 | Tapatío | 17:00 |
| USA | 2 - 1 | Costa Rica | 18:00 |
| Canada | 4 - 1 | Panama | 18:30 |
| Cancún | 0 - 1 | Monarcas | 19:05 |
| Honduras | 0 - 2 | Jamaica | 19:05 |
| El Salvador | 0 - 2 | Mexico | 21:05 |
| Cerro | 1 - 0 | Racing Montevideo | 19:30 |
| Magallanes | 3 - 0 | Universidad de Concepcion | 10:00 |
| D. Puerto Montt | 1 - 3 | Coquimbo Unido | 16:30 |
| Atletico-MG | 3 - 1 | Santos | 17:00 |
| Flamengo | 3 - 1 | Juventude | 17:00 |
| Chapecoense-sc | 1 - 1 | Atletico Paranaense | 17:00 |
| Fortaleza EC | 1 - 0 | Gremio | 18:30 |
| Corinthians | 1 - 0 | Fluminense | 19:00 |
| Internacional | 3 - 1 | America Mineiro | 19:30 |
| Chacaritas | 2 - 2 | America de Quito | 15:00 |
| Cumbayá | 4 - 3 | LDU Portoviejo | 15:00 |
| Guayaquil | 4 - 3 | Duros del Balon | 15:30 |
| Gualaceo SC | 1 - 0 | Puerto Quito | 15:30 |
| UT Cotopaxi | 1 - 1 | El Nacional | 15:30 |
