| Local | Visita | Hora | |
|---|---|---|---|
| Martes 28 de Septiembre | |||
| Shakhtar Donetsk | 0 - 0 | Inter | 11:45 |
| Ajax | 2 - 0 | Besiktas | 11:45 |
| FC Porto | 1 - 5 | Liverpool | 14:00 |
| RB Leipzig | 1 - 2 | Club Brugge KV | 14:00 |
| Paris Saint Germain | 2 - 0 | Manchester City | 14:00 |
| Real Madrid | 1 - 2 | Sheriff | 14:00 |
| Borussia Dortmund | 1 - 0 | Sporting CP | 14:00 |
| AC Milan | 1 - 2 | Atletico Madrid | 14:00 |
| Middlesbrough | 2 - 0 | Sheffield Utd | 13:45 |
| Cardiff | 0 - 4 | West Brom | 13:45 |
| Tepatitlán | 1 - 1 | Raya2 | 17:00 |
| Correcaminos Uat | 1 - 0 | Celaya | 19:05 |
| Necaxa | 3 - 0 | Club Tijuana | 17:00 |
| Mazatlán | 3 - 1 | FC Juarez | 19:00 |
| Atlas | 0 - 1 | Puebla | 21:00 |
| Pachuca | 1 - 1 | Club America | 21:05 |
| Cerro | 0 - 0 | Central Espanol | 17:00 |
| Danubio | 2 - 0 | Racing Montevideo | 19:30 |
| San Marcos de Arica | 0 - 0 | Coquimbo Unido | 17:00 |
| D. La Serena | 0 - 2 | Everton de Vina | 14:00 |
| OHiggins | 2 - 0 | Huachipato | 19:00 |
| All Boys | 2 - 0 | Defensores De Belgrano | 19:10 |
| Coritiba | 1 - 1 | Confiança | 19:30 |
| Cumbayá | 0 - 2 | Chacaritas | 19:00 |
| Atletico-MG | 1 - 1 | Palmeiras | 19:30 |
