| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 27 de Septiembre | |||
| Atlético Saltillo | 1 - 1 | Durango | 16:30 |
| Argentinos JRS | 4 - 1 | Academia Santa Cruz | 15:00 |
| Venezia | 1 - 1 | Torino | 13:45 |
| Crystal Palace | 1 - 1 | Brighton | 14:00 |
| Paços de Ferreira | 2 - 2 | Belenenses | 13:00 |
| Celta Vigo | 1 - 0 | Granada CF | 14:00 |
| Boavista | 1 - 1 | Estoril | 15:15 |
| Jong Ajax | 3 - 1 | MVV | 13:00 |
| Toulouse | 2 - 3 | Caen | 13:45 |
| Santos Laguna W | 2 - 2 | Monterrey W | 17:00 |
| SOL DE America | 2 - 1 | Club Guarani | 18:30 |
| Toluca W | 1 - 1 | Puebla W | 19:00 |
| Pumas UNAM W | 3 - 0 | Juárez W | 19:00 |
| León W | 1 - 1 | Necaxa W | 19:00 |
| Tigres UANL W | 3 - 0 | Tijuana W | 19:00 |
| Guadalajara W | 2 - 1 | Pachuca W | 21:00 |
| Magallanes | 2 - 2 | Deportes Iquique | 10:00 |
| Cusco | 3 - 2 | Academia Cantolao | 11:00 |
| Deportivo Binacional | 1 - 0 | U. San Martin | 15:30 |
| Vasco DA Gama | 2 - 0 | Goias | 18:00 |
| Deportivo Moron | 0 - 2 | Brown DE Adrogue | 19:30 |
| Argentinos JRS | 2 - 0 | Racing Club | 16:00 |
| Newells Old Boys | 0 - 1 | Huracan | 18:15 |
| Tacuary | 1 - 0 | General Diaz | 09:00 |
| General Caballero | 4 - 1 | Rubio NU | 13:45 |
| Chico | 2 - 0 | Valledupar | 18:00 |
| Huila | 1 - 1 | La Equidad | 20:00 |
