| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 17 de Septiembre | |||
| Brescia | 2 - 2 | Crotone | 13:30 |
| Sassuolo | 0 - 1 | Torino | 13:45 |
| Sparta Rotterdam | 1 - 1 | NEC Nijmegen | 13:00 |
| Hertha Berlin | 2 - 1 | SpVgg Greuther Furth | 13:30 |
| Celta Vigo | 1 - 2 | Cadiz | 14:00 |
| Newcastle | 1 - 1 | Leeds | 14:00 |
| Strasbourg | 3 - 0 | Metz | 14:00 |
| FC Schalke 04 | 1 - 2 | Karlsruher SC | 11:30 |
| FC Volendam | 2 - 1 | VVV Venlo | 13:00 |
| Roda | 2 - 0 | FC OSS | 13:00 |
| NAC Breda | 1 - 2 | Emmen | 13:00 |
| De Graafschap | 3 - 1 | Excelsior | 13:00 |
| Almere City FC | 2 - 4 | Jong Ajax | 13:00 |
| Necaxa | 0 - 3 | Atlas | 21:00 |
| Inter Miami | 0 - 4 | New York Red Bulls | 18:00 |
