| Local | Visita | Hora | |
|---|---|---|---|
| Martes 14 de Septiembre | |||
| Seattle Sounders | 1 - 0 | Santos Laguna | 21:00 |
| Maccabi Haifa | 0 - 0 | Feyenoord | 09:30 |
| Sevilla | 1 - 1 | Red Bull Salzburg | 11:45 |
| BSC Young Boys | 2 - 1 | Manchester United | 11:45 |
| Malmo FF | 0 - 3 | Juventus | 14:00 |
| Chelsea | 1 - 0 | Zenit Saint Petersburg | 14:00 |
| Lille | 0 - 0 | VfL Wolfsburg | 14:00 |
| Villarreal | 2 - 2 | Atalanta | 14:00 |
| Barcelona | 0 - 3 | Bayern Munich | 14:00 |
| Sheffield Utd | 2 - 2 | Preston | 13:45 |
| West Brom | 0 - 0 | Derby | 14:00 |
| Alebrijes de Oaxaca | 2 - 1 | Mineros de Zacatecas | 17:00 |
| Tampico Madero | 0 - 2 | Tlaxcala | 19:05 |
| Correcaminos Uat | 0 - 2 | Pumas Tabasco | 21:05 |
| Columbus Crew | 2 - 1 | New York Red Bulls | 18:30 |
| Toronto FC | 0 - 1 | Inter Miami | 18:30 |
| New York City FC | 3 - 3 | FC Dallas | 18:30 |
