| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 27 de Agosto | |||
| Udinese | 3 - 0 | Venezia | 11:30 |
| Verona | 1 - 3 | Inter | 13:45 |
| Fortuna Sittard | 2 - 2 | Waalwijk | 13:00 |
| Las Palmas | 2 - 1 | Huesca | 13:00 |
| Mallorca | 1 - 0 | Espanyol | 13:00 |
| Borussia Dortmund | 3 - 2 | 1899 Hoffenheim | 13:30 |
| Valencia | 3 - 0 | Alaves | 15:15 |
| Jong Ajax | 1 - 2 | Excelsior | 13:00 |
| Belenenses | 1 - 1 | Moreirense | 13:00 |
| VVV Venlo | 0 - 1 | Jong AZ | 13:00 |
| FC Volendam | 5 - 0 | MVV | 13:00 |
| Roda | 3 - 4 | Almere City FC | 13:00 |
| NAC Breda | 3 - 0 | ADO Den Haag | 13:00 |
| Emmen | 0 - 2 | De Graafschap | 13:00 |
| FC Eindhoven | 1 - 0 | Den Bosch | 13:00 |
| Nantes | 0 - 1 | Lyon | 14:00 |
| Estoril | 2 - 1 | Marítimo | 15:15 |
| Mazatlán | 2 - 2 | Atletico San Luis | 19:00 |
| Puebla | 1 - 0 | Club Queretaro | 21:00 |
| Club Tijuana | 2 - 2 | Monterrey | 21:06 |
| Magallanes | 0 - 1 | Santiago Morning | 14:00 |
| Deportivo Binacional | 3 - 1 | Ayacucho FC | 11:00 |
| FBC Melgar | 0 - 1 | Sporting Cristal | 13:15 |
| Cusco | 2 - 2 | Cienciano | 15:30 |
| Emelec | 4 - 0 | CD Olmedo | 19:00 |
| Coritiba | 0 - 1 | Botafogo | 19:30 |
| Temperley | 0 - 0 | Alvarado | 15:10 |
| Columbus Crew | 3 - 2 | FC Cincinnati | 17:30 |
| Montreal Impact | 3 - 1 | Toronto FC | 18:30 |
| Orlando City SC | 0 - 0 | Inter Miami | 19:30 |
| Quindio | 2 - 1 | Once Caldas | 19:40 |
