| Local | Visita | Hora | |
|---|---|---|---|
| Martes 24 de Agosto | |||
| 24 de Setiembre | 0 - 3 | Guairena FC | 18:30 |
| Norwich | 6 - 0 | Bournemouth | 13:00 |
| Sheffield Utd | 2 - 1 | Derby | 13:45 |
| Watford | 1 - 0 | Crystal Palace | 13:45 |
| Huddersfield | 1 - 2 | Everton | 13:45 |
| Birmingham | 0 - 2 | Fulham | 13:45 |
| Cardiff | 0 - 2 | Brighton | 13:45 |
| Brentford | 3 - 1 | Forest Green | 13:45 |
| Barrow | 0 - 6 | Aston Villa | 13:45 |
| Leeds | 3 - 0 | Crewe | 13:45 |
| Nottingham Forest | 0 - 4 | Wolves | 14:00 |
| PSV Eindhoven | 0 - 0 | Benfica | 14:00 |
| Tepatitlán | 2 - 0 | Venados FC | 17:00 |
| Pumas Tabasco | 0 - 2 | Dorados | 19:05 |
| Tampico Madero | 1 - 1 | Tapatío | 21:05 |
| Deportes Copiapo | 2 - 2 | D. Puerto Montt | 11:00 |
| Atlanta | 1 - 0 | Belgrano | 13:05 |
| Patronato | 1 - 1 | Banfield | 12:15 |
| Colon Santa Fe | 1 - 1 | Sarmiento Junin | 14:30 |
| Atletico Tucuman | 2 - 0 | Independiente | 16:45 |
| Racing Club | 0 - 0 | Central Cordoba de Santiago | 19:00 |
| Resistencia | 3 - 0 | Fulgencio Yegros | 09:00 |
| UT Cotopaxi | 1 - 1 | Puerto Quito | 15:00 |
| Cumbayá | 0 - 0 | El Nacional | 19:00 |
