| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 12 de Agosto | |||
| Orlando City SC | 0 - 1 | Santos Laguna | 18:00 |
| Feyenoord | 3 - 0 | FC Luzern | 13:00 |
| Olimpija | 0 - 1 | Santa Clara | 13:00 |
| Larne | 1 - 0 | Paços de Ferreira | 13:30 |
| Dundalk | 1 - 2 | Vitesse | 14:00 |
| Tepatitlán | 3 - 2 | Mineros de Zacatecas | 16:00 |
| Leones Negros UDG | 0 - 0 | Dorados | 20:00 |
| Club America | 2 - 0 | Philadelphia Union | 21:00 |
| Atletico San Luis | 0 - 2 | Necaxa | 21:00 |
| LDU de Quito | 1 - 0 | Atletico Paranaense | 17:15 |
| Santos | 2 - 1 | Libertad | 19:30 |
| Rocha | 1 - 3 | Cerro | 16:00 |
| Juventud | 2 - 0 | Racing Montevideo | 18:30 |
| Operario-PR | 1 - 0 | Botafogo | 19:30 |
| Fluminense | 2 - 2 | Barcelona SC | 19:30 |
