| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 11 de Agosto | |||
| Nottingham Forest | 2 - 1 | Bradford | 13:45 |
| Chelsea | 1 - 1 | Villarreal | 14:00 |
| New York City FC | 1 - 1 | U.N.A.M. - Pumas | 19:00 |
| Atalanta | 7 - 1 | Alessandria | 10:00 |
| Tlaxcala | 1 - 1 | Alebrijes de Oaxaca | 17:00 |
| Monterrey | 1 - 0 | Cruz Azul | 21:00 |
| Cimarrones | 2 - 0 | Atlante FC | 21:05 |
| Huachipato | 0 - 1 | Union Espanola | 19:00 |
| Estudiantes de Rio Cuarto | 1 - 1 | Talleres Cordoba | 19:30 |
| Sporting Cristal | 1 - 3 | Peñarol | 17:15 |
| Brasil DE Pelotas | 0 - 2 | Coritiba | 14:00 |
| Cruzeiro | 2 - 2 | Vitoria | 17:00 |
| Chacaritas | 1 - 0 | LDU Portoviejo | 15:00 |
| Gualaceo SC | 1 - 0 | El Nacional | 15:00 |
| Guayaquil | 0 - 1 | Puerto Quito | 19:00 |
| Olimpia | 1 - 4 | Flamengo | 17:15 |
| River Plate | 0 - 1 | Atletico-MG | 19:30 |
