| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 05 de Agosto | |||
| Tapatío | 1 - 2 | Pumas Tabasco | 19:00 |
| Vitesse | 2 - 2 | Dundalk | 12:00 |
| Paços de Ferreira | 4 - 0 | Larne | 13:00 |
| FC Luzern | 0 - 3 | Feyenoord | 13:30 |
| Popayan | 0 - 1 | Deportivo Pereira | 15:00 |
| Llaneros | 2 - 2 | Chico | 15:00 |
| Santa Clara | 2 - 0 | Olimpija | 15:30 |
| Envigado | 1 - 2 | Bucaramanga | 17:30 |
| Once Caldas | 1 - 3 | Independiente Medellin | 17:40 |
| Udinese | 4 - 0 | Cjarlins Muzane | 19:00 |
| Real Sociedad | 1 - 3 | Osasuna | 19:00 |
| Spal | 1 - 2 | Cremonese | 19:00 |
| Alaves | 4 - 3 | Al Nasr | 19:00 |
| Barranquilla | 2 - 0 | Jaguares | 20:00 |
| Club Queretaro | 0 - 1 | Leon | 21:05 |
| Juazeirense | 2 - 0 | Santos | 17:15 |
| Coquimbo Unido | 3 - 0 | Fernández Vial | 19:00 |
| ABC | 0 - 1 | Flamengo | 19:30 |
| Liverpool | 2 - 0 | Bologna | 09:00 |
| Defensor Sporting | 1 - 0 | Rampla Juniors | 13:00 |
| Cerro | 1 - 1 | Danubio | 18:00 |
| Cultural Santa Rosa | 0 - 1 | Union Comercio | 13:00 |
| Atletico Grau | 2 - 2 | Sport Chavelines Juniors | 18:00 |
