| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 30 de Abril | |||
| Werder Bremen | 1 - 1 | RB Leipzig | 13:30 |
| Parana | 0 - 1 | Atletico Paranaense | 14:00 |
| UTC | 1 - 3 | Ayacucho FC | 11:00 |
| U. San Martin | 1 - 0 | Academia Cantolao | 15:30 |
| Sport Boys | 3 - 1 | Deportivo Municipal | 18:00 |
| Everton de Vina | 0 - 4 | D. La Serena | 19:00 |
| Instituto Cordoba | 1 - 2 | Gimnasia Jujuy | 13:00 |
| Brown DE Adrogue | 2 - 0 | Almagro | 13:00 |
| CA Estudiantes | 2 - 1 | Deportivo Maipu | 15:10 |
| Velez Sarsfield | 1 - 0 | Patronato | 16:00 |
| Colon Santa Fe | 2 - 0 | Arsenal Sarandi | 19:00 |
| 12 de Octubre | 1 - 0 | Sportivo Luqueno | 19:15 |
| Paços de Ferreira | 1 - 0 | Belenenses | 09:00 |
| Guimaraes | 2 - 0 | Moreirense | 11:00 |
| Tondela | 0 - 2 | Benfica | 13:00 |
| FC Porto | 3 - 2 | Famalicao | 15:15 |
| Southampton | 1 - 1 | Leicester | 14:00 |
| Celta Vigo | 2 - 0 | Levante | 14:00 |
| Marseille | 1 - 1 | Strasbourg | 14:00 |
| Roda | 0 - 1 | Jong AZ | 13:00 |
| MVV | 2 - 2 | FC Volendam | 13:00 |
| Excelsior | 3 - 0 | Dordrecht | 13:00 |
| Almere City FC | 1 - 0 | Jong Ajax | 13:00 |
| Cambuur | 1 - 1 | De Graafschap | 13:00 |
| FC Eindhoven | 1 - 0 | Den Bosch | 13:00 |
| Celaya | 3 - 3 | Atlante FC | 17:00 |
| Cruz Azul W | 2 - 5 | Querétaro W | 12:45 |
| Necaxa | 1 - 5 | Atlas | 19:30 |
| FC Juarez | 1 - 0 | Toluca | 21:30 |
