| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 28 de Abril | |||
| Columbus Crew | 2 - 1 | Monterrey | 19:30 |
| Portland Timbers | 0 - 1 | Club America | 21:30 |
| Deportivo Madryn | 0 - 1 | Banfield | 13:10 |
| Independiente | 3 - 1 | Torque | 17:15 |
| Atletico Paranaense | 1 - 0 | Metropolitanos FC | 17:15 |
| Rosario Central | 2 - 0 | San Lorenzo | 19:30 |
| Deportes Tolima | 1 - 1 | Talleres Cordoba | 19:30 |
| Emelec | 3 - 0 | Bragantino | 19:30 |
| FBC Melgar | 2 - 0 | Aucas | 19:30 |
| General Caballero | 2 - 0 | Sportivo Trinidense | 09:00 |
| 3 de Febrero | 3 - 0 | Tacuary | 16:00 |
| Cuiaba | 3 - 1 | Dom Bosco | 18:30 |
| Cerro Porteño | 0 - 0 | Deportivo La Guaira | 17:00 |
| Olimpia | 2 - 1 | Always Ready | 21:00 |
| Paris Saint Germain | 1 - 2 | Manchester City | 14:00 |
| Defensa Y Justicia | 3 - 0 | Universitario | 17:00 |
| Barcelona SC | 4 - 0 | The Strongest | 21:00 |
| Nacional | 4 - 4 | Atletico Nacional | 17:00 |
| River Plate | 2 - 1 | Junior | 19:00 |
| Santa Fe | 1 - 2 | Fluminense | 19:00 |
| Leones FC | 1 - 1 | Huila | 19:40 |
| SpVgg Greuther Furth | 3 - 2 | SV Sandhausen | 11:30 |
| Athletic Club | 2 - 2 | Valladolid | 12:00 |
| Tepatitlán | 2 - 0 | Cimarrones | 17:00 |
