| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 23 de Abril | |||
| Sporting Kansas City | POSP | Orlando City SC | 18:30 |
| Academia Cantolao | 0 - 1 | UTC | 13:15 |
| Deportivo Municipal | 2 - 1 | Deportivo Binacional | 15:30 |
| Ayacucho FC | 1 - 1 | Cienciano | 18:00 |
| Curico Unido | 1 - 1 | Everton de Vina | 19:00 |
| Guarani Campinas | 1 - 2 | Palmeiras | 18:00 |
| Novorizontino | 1 - 0 | Santos | 20:15 |
| Sao Paulo | 2 - 0 | Santo André | 18:00 |
| Godoy Cruz | 1 - 0 | Central Cordoba de Santiago | 19:15 |
| Cortulua | 3 - 1 | Huila | 16:00 |
| Durango | 0 - 0 | Cafetaleros Chiapas II | 20:30 |
| Willem II | 1 - 0 | Waalwijk | 11:45 |
| Estoril | 1 - 1 | Casa Pia | 14:15 |
| FC Augsburg | 2 - 3 | FC Koln | 13:30 |
| Arsenal | 0 - 1 | Everton | 14:00 |
| Reims | 1 - 3 | Marseille | 14:00 |
| NAC Breda | 1 - 2 | Excelsior | 11:45 |
| Helmond Sport | 1 - 0 | FC Eindhoven | 11:45 |
| Jong Utrecht | 0 - 1 | GO Ahead Eagles | 14:00 |
| De Graafschap | 2 - 2 | Almere City FC | 14:00 |
| Dordrecht | 0 - 1 | MVV | 14:00 |
| Jong Ajax | 0 - 1 | NEC Nijmegen | 14:00 |
| Jong AZ | 2 - 4 | Cambuur | 14:00 |
| Den Bosch | 7 - 0 | Roda | 14:00 |
| Necaxa W | 1 - 0 | Pachuca W | 16:00 |
| Puebla | 0 - 0 | U.N.A.M. - Pumas | 19:30 |
| Club Tijuana | 1 - 0 | Necaxa | 21:06 |
| Mazatlán | 4 - 3 | Leon | 21:30 |
