| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 22 de Abril | |||
| Talleres Cordoba | 1 - 2 | Emelec | 14:00 |
| Gremio | 2 - 1 | La Equidad | 17:15 |
| Bragantino | 2 - 1 | Deportes Tolima | 17:15 |
| Aragua FC | 0 - 1 | Lanus | 17:15 |
| Bolívar | 2 - 1 | Arsenal Sarandi | 17:15 |
| Peñarol | 5 - 1 | Sport Huancayo | 19:30 |
| Club River Plate | 0 - 0 | Corinthians | 19:30 |
| Libertad | 2 - 0 | Palestino | 19:30 |
| Atletico Paranaense | 3 - 1 | Cascavel CR | 14:00 |
| Atletico Nacional | 2 - 0 | U. Catolica | 19:00 |
| El Nacional | 4 - 0 | UT Cotopaxi | 19:00 |
| Goias | 0 - 2 | Iporá | 13:30 |
| Fluminense | 1 - 1 | River Plate | 17:00 |
| Junior | 1 - 1 | Santa Fe | 21:00 |
| Ajax | 1 - 1 | Utrecht | 11:45 |
| Gil Vicente | 0 - 3 | Famalicao | 11:00 |
| Portimonense | 1 - 5 | Benfica | 13:00 |
| FC Porto | 1 - 0 | Guimaraes | 15:00 |
| SV Sandhausen | 2 - 1 | Hamburger SV | 13:30 |
| Atletico Madrid | 2 - 0 | Huesca | 12:00 |
| Real Sociedad | 2 - 1 | Celta Vigo | 14:00 |
| Granada CF | 4 - 1 | Eibar | 14:00 |
| Barcelona | 5 - 2 | Getafe | 15:00 |
| AS Roma | 1 - 1 | Atalanta | 11:30 |
| Napoli | 5 - 2 | Lazio | 13:45 |
| Tapatío | 1 - 0 | Tlaxcala | 21:00 |
| Querétaro W | 2 - 1 | Tijuana W | 17:00 |
