| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 14 de Abril | |||
| Toronto FC | 2 - 1 | Leon | 17:00 |
| Club America | 0 - 1 | CD Olimpia | 19:00 |
| Philadelphia Union | 3 - 0 | Deportivo Saprissa | 19:00 |
| Liverpool | 0 - 0 | Real Madrid | 14:00 |
| Borussia Dortmund | 1 - 2 | Manchester City | 14:00 |
| FC Juarez | 2 - 3 | Tigres UANL | 21:00 |
| Clermont Foot | 3 - 0 | Amiens | 12:00 |
| Rayo Vallecano | 0 - 1 | Mirandes | 12:00 |
| Leones Negros UDG | 1 - 1 | Alebrijes de Oaxaca | 17:00 |
| Venados FC | 0 - 1 | Atlante FC | 19:05 |
| Pumas Tabasco | 1 - 2 | Cancún | 21:05 |
