| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 14 de Abril | |||
| Toronto FC | 2 - 1 | Leon | 17:00 |
| Fenix | 0 - 2 | Torque | 17:15 |
| Club America | 0 - 1 | CD Olimpia | 19:00 |
| Philadelphia Union | 3 - 0 | Deportivo Saprissa | 19:00 |
| Palmeiras | 1 - 2 | Defensa Y Justicia | 19:30 |
| ABC | 1 - 1 | Botafogo | 19:30 |
| America-RN | 0 - 1 | Cruzeiro | 19:30 |
| Gremio | 1 - 2 | Independiente del Valle | 17:15 |
| San Martin S.J. | 2 - 2 | Racing Club | 19:10 |
| Atletico Nacional | 4 - 1 | Libertad | 19:30 |
| Academia Cantolao | 0 - 2 | Cienciano | 13:15 |
| Sport Huancayo | 0 - 0 | Alianza Lima | 15:30 |
| Cesar Vallejo | 2 - 1 | Carlos A. Mannucci | 18:00 |
| Chacaritas | 1 - 0 | Puerto Quito | 15:00 |
| UT Cotopaxi | 2 - 0 | Gualaceo SC | 15:00 |
| Sao Paulo | 3 - 2 | Guarani Campinas | 19:30 |
| Delfin SC | 2 - 0 | Macara | 12:15 |
| LDU de Quito | 1 - 0 | Manta FC | 14:30 |
| Universidad Catolica | 2 - 3 | Emelec | 17:00 |
| Goias | 1 - 1 | Aparecidense | 19:30 |
| Aimoré | 1 - 6 | Internacional | 19:30 |
| Liverpool | 0 - 0 | Real Madrid | 14:00 |
| Borussia Dortmund | 1 - 2 | Manchester City | 14:00 |
| FC Juarez | 2 - 3 | Tigres UANL | 21:00 |
| Clermont Foot | 3 - 0 | Amiens | 12:00 |
| Rayo Vallecano | 0 - 1 | Mirandes | 12:00 |
| Leones Negros UDG | 1 - 1 | Alebrijes de Oaxaca | 17:00 |
| Venados FC | 0 - 1 | Atlante FC | 19:05 |
| Pumas Tabasco | 1 - 2 | Cancún | 21:05 |
