| Local | Visita | Hora | |
|---|---|---|---|
| Martes 13 de Abril | |||
| Atlanta United FC | 1 - 0 | LD Alajuelense | 17:00 |
| Portland Timbers | 4 - 0 | CD Marathon | 19:00 |
| Peñarol | 4 - 1 | Cerro Largo | 19:30 |
| Cruz Azul | 8 - 0 | Arcahaie | 21:30 |
| Santos | 2 - 2 | San Lorenzo | 19:30 |
| Cusco | 2 - 2 | Sport Boys | 13:15 |
| Deportivo Binacional | 2 - 1 | Alianza Universidad | 15:30 |
| Sporting Cristal | 3 - 1 | Deportivo Municipal | 18:00 |
| San Martin Tucuman | 0 - 1 | Chacarita Juniors | 17:15 |
| Ferroviária | 2 - 1 | Corinthians | 18:00 |
| 9 de Octubre | 4 - 0 | Guayaquil City FC | 14:30 |
| CD Olmedo | 2 - 2 | Deportivo Cuenca | 17:00 |
| Lanus | 1 - 3 | Newells Old Boys | 17:00 |
| Huracan | 3 - 0 | Sarmiento Junin | 17:00 |
| Paris Saint Germain | 0 - 1 | Bayern Munich | 14:00 |
| Chelsea | 0 - 0 | FC Porto | 14:00 |
| Patriotas | 1 - 1 | Once Caldas | 20:00 |
| Mafra | 0 - 4 | Casa Pia | 14:30 |
| Cremonese | 2 - 2 | Empoli | 09:00 |
| Tlaxcala | 2 - 1 | Mineros de Zacatecas | 17:00 |
| Tampico Madero | 0 - 0 | Dorados | 19:05 |
| Cimarrones | 2 - 0 | Correcaminos Uat | 21:05 |
| Huddersfield | 1 - 2 | Bournemouth | 11:30 |
