| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 08 de Abril | |||
| Club River Plate | 4 - 2 | Guairena FC | 17:15 |
| Guayaquil City FC | 0 - 3 | Aucas | 17:15 |
| Real Estelí | 0 - 4 | Columbus Crew | 19:00 |
| FBC Melgar | 3 - 2 | Carlos A. Mannucci | 19:30 |
| Deportivo Pasto | 0 - 2 | La Equidad | 19:30 |
| Palestino | 2 - 1 | Cobresal | 19:30 |
| Atlético Pantoja | 0 - 3 | Monterrey | 21:00 |
| Montreal Impact | 0 - 2 | Tormenta | 10:00 |
| Bolívar | 2 - 1 | Junior | 19:30 |
| El Nacional | 2 - 0 | Cumbayá | 17:00 |
| RED Star FC 93 | 2 - 2 | Lyon | 12:00 |
| Mushuc Runa SC | 4 - 0 | CD Olmedo | 14:30 |
| Deportivo Cuenca | 1 - 0 | Barcelona SC | 17:00 |
| America Mineiro | 1 - 1 | CAP | 15:30 |
| Granada CF | 0 - 2 | Manchester United | 14:00 |
| Dinamo Zagreb | 0 - 1 | Villarreal | 14:00 |
| Ajax | 1 - 2 | AS Roma | 14:00 |
| Arsenal | 1 - 1 | Slavia Praha | 14:00 |
| Tapatío | 1 - 1 | Venados FC | 19:00 |
