| Local | Visita | Hora | |
|---|---|---|---|
| Martes 06 de Abril | |||
| CD Marathon | 2 - 2 | Portland Timbers | 17:00 |
| Nacional Asuncion | 0 - 0 | 12 de Octubre | 17:15 |
| Emelec | 2 - 0 | Macara | 17:15 |
| LD Alajuelense | 0 - 1 | Atlanta United FC | 19:00 |
| Huachipato | 3 - 0 | Antofagasta | 19:30 |
| Deportivo Cali | 0 - 0 | Deportes Tolima | 19:30 |
| Cerro Largo | 2 - 2 | Peñarol | 19:30 |
| Arcahaie | 0 - 0 | Cruz Azul | 21:00 |
| Alianza Lima | 1 - 0 | Deportivo Municipal | 15:30 |
| Fortaleza EC | 1 - 0 | Ypiranga-RS | 19:30 |
| Inter Miami | 1 - 0 | Miami FC | 19:00 |
| New England Revolution | CANC | Seattle Sounders | 19:00 |
| Patronato | 2 - 2 | Lanus | 19:10 |
| San Lorenzo | 1 - 3 | Santos | 19:30 |
| Puerto Quito | 1 - 1 | UT Cotopaxi | 14:00 |
| Duros del Balon | 1 - 3 | Chacaritas | 17:00 |
| Monaco | 0 - 0 | Metz | 11:45 |
| Real Madrid | 3 - 1 | Liverpool | 14:00 |
| Manchester City | 2 - 1 | Borussia Dortmund | 14:00 |
| Deportivo Pereira | 1 - 0 | Independiente Medellin | 18:00 |
| Alianza Petrolera | 0 - 3 | Santa Fe | 20:00 |
| Macaé | 0 - 4 | Fluminense | 19:35 |
| FC Heidenheim | 1 - 0 | Holstein Kiel | 11:30 |
| Casa Pia | 1 - 2 | Chaves | 13:00 |
| Tepatitlán | 2 - 1 | Tlaxcala | 17:00 |
| Correcaminos Uat | 1 - 2 | Celaya | 19:05 |
| Alebrijes de Oaxaca | 4 - 1 | Tampico Madero | 21:05 |
| Brentford | 0 - 0 | Birmingham | 13:00 |
| Norwich | 7 - 0 | Huddersfield | 13:45 |
