| Viernes 02 de Abril |
| Antofagasta | 1 - 2 | Everton de Vina | 13:00 |
| Patronato | 2 - 0 | Aldosivi | 14:00 |
| San Lorenzo | 2 - 0 | Rosario Central | 16:15 |
| Central Cordoba de Santiago | 0 - 1 | Platense | 18:15 |
| Santa Fe | 1 - 1 | Deportivo Pereira | 18:40 |
| Mineros de Fresnillo | 0 - 1 | Durango | 17:00 |
| Nacional | 1 - 5 | Portimonense | 13:30 |
| Levante | 0 - 2 | Huesca | 13:00 |
| Frosinone | 0 - 0 | Reggiana | 09:00 |
| GO Ahead Eagles | 0 - 0 | Roda | 10:00 |
| Venezia | 0 - 2 | Reggina | 11:00 |
| Virtus Entella | 1 - 1 | Monza | 11:00 |
| Lecce | 2 - 0 | Salernitana | 11:00 |
| Jong Ajax | 1 - 1 | NAC Breda | 12:00 |
| Almere City FC | 2 - 0 | NEC Nijmegen | 12:00 |
| Excelsior | 0 - 0 | Jong PSV | 12:00 |
| FC Volendam | 0 - 3 | Cambuur | 12:00 |
| MVV | 2 - 0 | FC Eindhoven | 12:00 |
| De Graafschap | 0 - 3 | Dordrecht | 12:00 |
| Tepatitlán | 1 - 0 | Cimarrones | 17:00 |
| Almeria | 0 - 1 | Rayo Vallecano | 13:00 |
| Querétaro W | 1 - 0 | León W | 17:00 |
| Puebla | 3 - 1 | Mazatlán | 19:30 |
| FC Juarez | 0 - 1 | Cruz Azul | 21:30 |
| Preston | 1 - 1 | Norwich | 08:00 |
| Derby | 2 - 0 | Luton | 08:00 |
| Cardiff | 0 - 1 | Nottingham Forest | 08:00 |
| Bournemouth | 3 - 1 | Middlesbrough | 08:00 |
| Watford | 1 - 0 | Sheffield Wednesday | 08:00 |
