| Local | Visita | Hora | |
|---|---|---|---|
| Martes 16 de Marzo | |||
| Macara | 2 - 2 | Emelec | 16:15 |
| Sergipe | 0 - 0 | Cuiaba | 16:15 |
| 12 de Octubre | 0 - 0 | Nacional Asuncion | 16:15 |
| Duros del Balon | 1 - 1 | Puerto Quito | 18:00 |
| Chacarita Juniors | 0 - 1 | Atlanta | 18:10 |
| Antofagasta | 0 - 1 | Huachipato | 18:30 |
| Deportes Tolima | 3 - 0 | Deportivo Cali | 18:30 |
| Bolívar | 5 - 0 | Wanderers | 16:15 |
| Deportivo Lara | 1 - 1 | Santos | 16:15 |
| Ayacucho FC | 1 - 2 | Gremio | 18:30 |
| Independiente del Valle | 6 - 2 | Union Espanola | 18:30 |
| Deportivo Pereira | 0 - 0 | Chico | 19:00 |
| Real Madrid | 3 - 1 | Atalanta | 14:00 |
| Manchester City | 2 - 0 | Borussia Monchengladbach | 14:00 |
| Virtus Entella | 0 - 2 | Cremonese | 09:00 |
| Venezia | 2 - 3 | Lecce | 10:00 |
| Cittadella | 0 - 0 | Salernitana | 12:00 |
| Monza | 2 - 0 | Reggiana | 12:00 |
| Empoli | 1 - 0 | Pordenone | 12:00 |
| Chievo | 0 - 0 | Frosinone | 12:00 |
| Mineros de Zacatecas | 2 - 0 | Monarcas | 17:00 |
| Venados FC | 2 - 1 | Cancún | 19:05 |
| Pumas Tabasco | 0 - 0 | Tampico Madero | 21:05 |
| Rotherham | 1 - 4 | Watford | 13:00 |
| Luton | 2 - 0 | Coventry | 13:00 |
| Derby | 2 - 2 | Brentford | 13:00 |
| Bournemouth | 3 - 0 | Swansea | 13:45 |
