| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 11 de Marzo | |||
| Palmeiras | 3 - 0 | São Caetano | 16:00 |
| Sao Raimundo | 1 - 1 | Cruzeiro | 16:15 |
| Real Cartagena | 2 - 1 | Huila | 16:30 |
| Boavista SC | 3 - 1 | Goias | 18:30 |
| Club Guarani | 0 - 2 | Atletico Nacional | 18:30 |
| Macara | 1 - 1 | Emelec | 18:00 |
| Deportivo Cali | 0 - 2 | America de Cali | 19:00 |
| Manchester United | 1 - 0 | AC Milan | 11:55 |
| Dynamo Kyiv | 0 - 2 | Villarreal | 11:55 |
| Ajax | 3 - 0 | BSC Young Boys | 11:55 |
| Olympiakos Piraeus | 1 - 3 | Arsenal | 14:00 |
| AS Roma | 3 - 0 | Shakhtar Donetsk | 14:00 |
| Granada CF | 2 - 0 | Molde | 14:00 |
| Tottenham | 2 - 0 | Dinamo Zagreb | 14:00 |
| Leones Negros UDG | 1 - 1 | Cimarrones | 21:00 |
| Santos Laguna W | 2 - 2 | Pumas UNAM W | 16:00 |
| León W | 0 - 3 | Monterrey W | 19:00 |
| Juárez W | 1 - 2 | Atlas W | 19:00 |
| Mazatlán W | 2 - 0 | Necaxa W | 20:00 |
| Guadalajara W | 1 - 1 | Toluca W | 21:00 |
