| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 19 de Febrero | |||
| Universidad Catolica | 3 - 0 | CD Olmedo | 15:30 |
| LDU de Quito | 4 - 2 | 9 de Octubre | 18:00 |
| Gimnasia L.P. | 3 - 0 | Talleres Cordoba | 16:15 |
| Defensores De Belgrano | 4 - 2 | Almirante Brown | 18:30 |
| Arsenal Sarandi | 0 - 2 | Banfield | 18:30 |
| Club River Plate | 1 - 0 | Sportivo Luqueno | 16:30 |
| Plaza Colonia | 3 - 0 | Boston River | 14:00 |
| Deportes Tolima | 3 - 1 | Patriotas | 19:00 |
| Boavista | 1 - 0 | Moreirense | 14:30 |
| Erzgebirge AUE | 1 - 0 | VfL BOCHUM | 11:30 |
| Arminia Bielefeld | 0 - 3 | VfL Wolfsburg | 13:30 |
| Jong Ajax | 1 - 1 | Cambuur | 09:30 |
| Fiorentina | 3 - 0 | Spezia | 11:30 |
| Willem II | 0 - 6 | Utrecht | 13:00 |
| Cagliari | 0 - 1 | Torino | 13:45 |
| Real Betis | 1 - 0 | Getafe | 14:00 |
| Frosinone | 0 - 0 | Pescara | 14:00 |
| Dordrecht | 2 - 3 | NAC Breda | 11:45 |
| Telstar | 1 - 1 | FC Eindhoven | 14:00 |
| Helmond Sport | 1 - 2 | Roda | 14:00 |
| Wolves | 1 - 0 | Leeds | 14:00 |
| Mineros de Zacatecas | 1 - 0 | Atlante FC | 17:00 |
| Stade Brestois 29 | 2 - 3 | Lyon | 14:00 |
| Necaxa | 1 - 1 | Monterrey | 19:30 |
| FC Juarez | 1 - 0 | Mazatlán | 21:30 |
| Watford | 2 - 1 | Derby | 13:45 |
| Sao Paulo | 1 - 1 | Palmeiras | 18:30 |
