| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 17 de Febrero | |||
| Real Santander | 2 - 2 | Huila | 17:30 |
| Velez Sarsfield | 3 - 1 | Deportivo Camioneros | 18:10 |
| NEC Nijmegen | 1 - 2 | VVV Venlo | 09:30 |
| Heerenveen | 4 - 3 | Feyenoord | 11:45 |
| Bucaramanga | 2 - 0 | Deportivo Pereira | 13:00 |
| Rionegro Aguilas | 1 - 1 | Envigado | 15:00 |
| Independiente Medellin | 1 - 0 | Chico | 17:05 |
| Junior | 1 - 2 | Deportivo Cali | 19:10 |
| River Plate | 1 - 1 | Rentistas | 07:00 |
| Liverpool | 2 - 1 | Wanderers | 14:00 |
| Peñarol | 1 - 1 | Cerro Largo | 16:30 |
| Cerro | 0 - 0 | Defensor Sporting | 18:45 |
| Sevilla | 2 - 3 | Borussia Dortmund | 14:00 |
| FC Porto | 2 - 1 | Juventus | 14:00 |
| Guimaraes | 2 - 2 | Farense | 15:45 |
| Celaya | 4 - 0 | Cancún | 17:00 |
| Venados FC | 1 - 0 | Tepatitlán | 19:05 |
| Dorados | 1 - 1 | Tlaxcala | 21:05 |
| Tigres UANL | 0 - 2 | Cruz Azul | 21:00 |
| Swansea | 1 - 0 | Nottingham Forest | 13:00 |
| QPR | 2 - 1 | Brentford | 13:00 |
| Coventry | 0 - 2 | Norwich | 13:00 |
| Bournemouth | 1 - 0 | Rotherham | 14:15 |
| Santos | 1 - 0 | Corinthians | 16:00 |
| Colo Colo | 1 - 0 | Universidad de Concepcion | 15:00 |
| Coritiba | 1 - 0 | Palmeiras | 16:30 |
