| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 12 de Febrero | |||
| Banfield | 2 - 0 | Racing Club | 16:15 |
| Union Santa Fe | 2 - 2 | Atletico Tucuman | 18:30 |
| Central Cordoba de Santiago | 0 - 3 | Colon Santa Fe | 18:30 |
| Deportivo Pereira | 1 - 2 | Patriotas | 15:00 |
| Alianza Petrolera | 0 - 0 | Once Caldas | 17:00 |
| Chico | 1 - 2 | America de Cali | 19:05 |
| Durango | 3 - 0 | Colima | 20:00 |
| Famalicao | 0 - 0 | Belenenses | 14:30 |
| Holstein Kiel | 1 - 0 | FC Wurzburger Kickers | 11:30 |
| RB Leipzig | 2 - 1 | FC Augsburg | 13:30 |
| Waalwijk | 1 - 0 | Emmen | 11:45 |
| Bologna | 1 - 1 | Benevento | 13:45 |
| Monza | 0 - 2 | Pisa | 14:00 |
| Celta Vigo | 3 - 1 | Elche | 14:00 |
| NAC Breda | 2 - 1 | FC Eindhoven | 09:30 |
| Necaxa W | 0 - 2 | Guadalajara W | 16:00 |
| Querétaro W | 1 - 2 | América W | 17:00 |
| Puebla | 4 - 0 | FC Juarez | 19:30 |
| Club Tijuana | 2 - 0 | Leon | 21:06 |
| Mazatlán | 0 - 3 | Atletico San Luis | 21:30 |
