| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 04 de Febrero | |||
| Tigres UANL | 2 - 1 | Ulsan Hyundai FC | 08:00 |
| Guayaquil City FC | 0 - 1 | Barcelona SC | 18:00 |
| River Plate | 0 - 4 | Danubio | 07:00 |
| Santa Fe | 1 - 0 | Patriotas | 13:00 |
| Plaza Colonia | 2 - 1 | Cerro | 14:00 |
| Torque | 0 - 0 | Defensor Sporting | 16:15 |
| Independiente Medellin | 0 - 0 | Millonarios | 19:00 |
| Real Betis | 1 - 1 | Athletic Club | 14:00 |
| Vitesse | 0 - 2 | Salitas | 08:30 |
| San Telmo | 0 - 0 | Deportivo Madryn | 18:30 |
| Farense | 1 - 1 | Santa Clara | 09:00 |
| Belenenses | 0 - 0 | FC Porto | 13:00 |
| SC Braga | 2 - 1 | Portimonense | 15:00 |
| Famalicao | 0 - 2 | Moreirense | 15:30 |
| Tottenham | 0 - 1 | Chelsea | 14:00 |
| Tampico Madero | 1 - 1 | Cancún | 16:00 |
| Tapatío | 2 - 1 | Atlante FC | 17:00 |
| Atlas W | 3 - 3 | Pachuca W | 10:00 |
| Toluca W | 2 - 1 | Puebla W | 12:00 |
| Necaxa W | 0 - 1 | América W | 16:00 |
| León W | 2 - 1 | Santos Laguna W | 17:00 |
| Monterrey W | 5 - 1 | Cruz Azul W | 19:00 |
| Atletico San Luis | 2 - 2 | Club Tijuana | 19:00 |
| Club Queretaro | 3 - 1 | Pachuca | 21:00 |
| Coquimbo Unido | 0 - 1 | Cobresal | 17:00 |
| Fortaleza EC | 3 - 1 | Coritiba | 15:30 |
| Atletico Paranaense | 0 - 0 | Internacional | 18:00 |
| Flamengo | 2 - 0 | Vasco DA Gama | 18:00 |
