| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 29 de Enero | |||
| Emelec | 0 - 0 | Tecnico Universitario | 18:00 |
| Fenix | 3 - 3 | Plaza Colonia | 14:00 |
| Boston River | 2 - 1 | Cerro Largo | 16:15 |
| Jaguares | 2 - 0 | Alianza Petrolera | 17:00 |
| Deportivo Cali | 1 - 1 | Envigado | 19:00 |
| Estrela | 2 - 1 | Real | 09:00 |
| SC Braga | 2 - 1 | Santa Clara | 13:45 |
| Gil Vicente | 0 - 2 | FC Porto | 14:45 |
| SpVgg Greuther Furth | 3 - 0 | Erzgebirge AUE | 11:30 |
| VfB Stuttgart | 2 - 0 | FSV Mainz 05 | 13:30 |
| Torino | 1 - 1 | Fiorentina | 13:45 |
| Vicenza Virtus | 0 - 0 | Venezia | 14:00 |
| Valladolid | 1 - 3 | Huesca | 14:00 |
| NEC Nijmegen | 2 - 0 | Jong Utrecht | 14:00 |
| De Graafschap | 2 - 1 | FC OSS | 14:00 |
| Lyon | 2 - 1 | Bordeaux | 14:00 |
| Atlante FC | 2 - 1 | Tlaxcala | 17:30 |
| Necaxa W | 1 - 1 | Pumas UNAM W | 15:45 |
| Mazatlán | 1 - 0 | Pachuca | 21:30 |
| Reading | 3 - 1 | Bournemouth | 14:00 |
| Coquimbo Unido | 0 - 1 | Universidad de Chile | 16:00 |
| CRB | 4 - 1 | Cuiaba | 16:15 |
| Parana | 0 - 0 | Cruzeiro | 18:30 |
| America Mineiro | 2 - 1 | Avai | 18:30 |
