| Miércoles 23 de Diciembre |
| FC Porto | 2 - 0 | Benfica | 14:45 |
| VfL Wolfsburg | 3 - 0 | SV Sandhausen | 11:30 |
| FSV Mainz 05 | 2 - 2 | VfL BOCHUM | 13:45 |
| Hannover 96 | 0 - 3 | Werder Bremen | 13:45 |
| VfB Stuttgart | 1 - 0 | SC Freiburg | 13:45 |
| Newells Old Boys | 2 - 0 | Sportivo Peñarol | 15:10 |
| Marítimo | 2 - 1 | Salgueiros | 05:00 |
| União de Leiria | 0 - 3 | Gil Vicente | 10:00 |
| Stoke City | 1 - 3 | Tottenham | 11:30 |
| Everton | 0 - 1 | Manchester United | 14:00 |
| Palmeiras | 1 - 1 | America Mineiro | 18:30 |
| Gremio | 1 - 0 | Sao Paulo | 18:30 |
| Sport Chavelines Juniors | 2 - 4 | Alianza Atletico | 14:00 |
| Boca Juniors | 2 - 0 | Racing Club | 18:30 |
| 12 de Octubre | 1 - 2 | Guairena FC | 15:30 |
| Libertad | 1 - 3 | Club Guarani | 18:00 |
| AZ Alkmaar | 3 - 1 | Vitesse | 09:30 |
| Verona | 1 - 2 | Inter | 11:30 |
| Willem II | 1 - 1 | Ajax | 11:45 |
| ADO Den Haag | 0 - 2 | PEC Zwolle | 13:00 |
| Groningen | 0 - 1 | Heracles | 13:00 |
| AS Roma | 3 - 2 | Cagliari | 13:45 |
| Napoli | 1 - 1 | Torino | 13:45 |
| AC Milan | 3 - 2 | Lazio | 13:45 |
| Bologna | 2 - 2 | Atalanta | 13:45 |
| Udinese | 0 - 2 | Benevento | 13:45 |
| Spezia | 1 - 2 | Genoa | 13:45 |
| Sampdoria | 2 - 3 | Sassuolo | 13:45 |
| Feyenoord | 3 - 0 | Heerenveen | 14:00 |
| Defensa Y Justicia | 2 - 1 | Estudiantes L.P. | 14:10 |
| Getafe | 1 - 1 | Celta Vigo | 10:30 |
| Real Madrid | 2 - 0 | Granada CF | 12:45 |
| Real Betis | 1 - 0 | Cadiz | 15:00 |
| Alaves | 2 - 1 | Eibar | 15:00 |
| Bordeaux | 1 - 3 | Reims | 12:00 |
| Lens | 2 - 1 | Stade Brestois 29 | 12:00 |
| Rennes | 1 - 0 | Metz | 12:00 |
| Nice | 2 - 2 | Lorient | 12:00 |
| Nimes | 1 - 3 | Dijon | 12:00 |
| Lyon | 3 - 0 | Nantes | 14:00 |
| Paris Saint Germain | 4 - 0 | Strasbourg | 14:00 |
| Montpellier | 2 - 3 | Lille | 14:00 |
| Monaco | 2 - 2 | Saint Etienne | 14:00 |
| Angers | 2 - 1 | Marseille | 14:00 |
| Universidad de Chile | 0 - 0 | U. Catolica | 15:30 |
| Coquimbo Unido | 0 - 1 | Antofagasta | 07:30 |
| Barcelona SC | 1 - 1 | LDU de Quito | 19:15 |
| Huila | 1 - 0 | Cortulua | 19:00 |
