| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 18 de Diciembre | |||
| CA Estudiantes | 3 - 3 | Atlanta | 18:10 |
| Union Comercio | 0 - 1 | Molinos El Pirata | 12:00 |
| Juan Aurich | 4 - 2 | Alianza Atletico | 12:00 |
| Arsenal Sarandi | 0 - 1 | Argentinos JRS | 18:10 |
| Portimonense | 0 - 0 | Famalicao | 14:30 |
| 12 de Octubre | 2 - 1 | Cerro Porteño | 16:30 |
| Sportivo Luqueno | 0 - 3 | SOL DE America | 16:30 |
| VfL BOCHUM | 3 - 0 | FC Heidenheim | 11:30 |
| PEC Zwolle | 0 - 0 | Emmen | 13:00 |
| Union Berlin | 2 - 1 | Borussia Dortmund | 13:30 |
| Frosinone | 0 - 0 | Salernitana | 14:00 |
| Athletic Club | 2 - 0 | Huesca | 14:00 |
| Police | 0 - 2 | Vitesse | 10:00 |
| Auxerre | 2 - 1 | PAU | 13:00 |
| Estac Troyes | 1 - 0 | Niort | 13:00 |
| Ajaccio | 1 - 0 | Nancy | 13:00 |
| NAC Breda | 3 - 0 | FC Volendam | 11:45 |
| Den Bosch | 1 - 1 | FC Eindhoven | 11:45 |
| MVV | 3 - 1 | Dordrecht | 14:00 |
| Avai | 1 - 1 | Cruzeiro | 17:15 |
| Cuiaba | 2 - 0 | Operario-PR | 19:30 |
