| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 06 de Noviembre | |||
| Patronato | 1 - 2 | Huracan | 16:00 |
| Argentinos JRS | 0 - 1 | Aldosivi | 18:15 |
| Club Guarani | 2 - 0 | General Diaz | 17:30 |
| FC Heidenheim | 4 - 1 | FC Wurzburger Kickers | 11:30 |
| Werder Bremen | 1 - 1 | FC Koln | 13:30 |
| Sassuolo | 0 - 0 | Udinese | 13:45 |
| Spal | 2 - 0 | Salernitana | 14:00 |
| Belenenses | 0 - 0 | Rio Ave | 14:30 |
| Brighton | 0 - 0 | Burnley | 11:30 |
| Fortuna Sittard | 2 - 2 | PEC Zwolle | 13:00 |
| Southampton | 2 - 0 | Newcastle | 14:00 |
| Feirense | 0 - 1 | Arouca | 12:30 |
| Elche | 1 - 1 | Celta Vigo | 14:00 |
| Strasbourg | 0 - 1 | Marseille | 14:00 |
| Cusco | 0 - 0 | Sport Huancayo | 10:00 |
| MVV | 1 - 4 | NAC Breda | 11:45 |
| Academia Cantolao | 2 - 2 | Universitario | 12:15 |
| Albacete | 0 - 0 | Leganes | 14:00 |
| NEC Nijmegen | 2 - 2 | Helmond Sport | 14:00 |
| Almere City FC | 2 - 0 | Jong AZ | 14:00 |
| Alianza Lima | 2 - 2 | Deportivo Llacuabamba | 14:30 |
| Ayacucho FC | 1 - 1 | Cesar Vallejo | 17:00 |
| Puebla | 1 - 0 | Atletico San Luis | 19:30 |
| FC Juarez | 1 - 1 | Club America | 21:30 |
| Envigado | 1 - 1 | La Equidad | 17:00 |
| Rionegro Aguilas | 2 - 1 | Cucuta | 19:00 |
| El Nacional | 1 - 3 | Delfin SC | 13:00 |
| LDU de Quito | 4 - 0 | Orense SC | 15:30 |
| Botafogo SP | 0 - 1 | Cruzeiro | 16:15 |
| CD Olmedo | 1 - 0 | Barcelona SC | 18:00 |
| Ayacucho FC | 1 - 1 | Cesar Vallejo | 17:00 |
