| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 25 de Septiembre | |||
| Monza | 0 - 0 | Spal | 09:45 |
| Vitesse | 0 - 1 | USFA | 10:30 |
| Erzgebirge AUE | 1 - 1 | SpVgg Greuther Furth | 11:30 |
| Hertha Berlin | 1 - 3 | Eintracht Frankfurt | 13:30 |
| SC Braga | 0 - 1 | Santa Clara | 14:30 |
| Twente | 3 - 1 | Groningen | 13:00 |
| Huddersfield | 1 - 0 | Nottingham Forest | 13:45 |
| Almere City FC | 2 - 0 | Helmond Sport | 11:45 |
| MVV | 3 - 0 | FC OSS | 14:00 |
| Lille | 2 - 0 | Nantes | 14:00 |
| Cambuur | 5 - 2 | Jong Utrecht | 14:00 |
| Jorge Wilstermann | 3 - 1 | Peñarol | 17:00 |
| Necaxa W | 0 - 1 | Monterrey W | 16:00 |
| Duros del Balon | 1 - 0 | Chacaritas | 14:15 |
| Jaguares | 2 - 0 | La Equidad | 18:00 |
| Once Caldas | 2 - 0 | Atletico Nacional | 20:05 |
| Chapecoense-sc | 0 - 0 | America Mineiro | 17:15 |
| Cruzeiro | 0 - 1 | Avai | 19:30 |
| Coquimbo Unido | 2 - 1 | Santiago Wanderers | 14:00 |
| Huachipato | 1 - 1 | D. La Serena | 16:30 |
| Puebla | 3 - 3 | Club Queretaro | 19:30 |
| FC Juarez | 0 - 1 | Atlas | 21:30 |
| El Nacional | 2 - 2 | Orense SC | 16:30 |
| Guairena FC | 3 - 3 | 12 de Octubre | 19:00 |
| Cesar Vallejo | 1 - 1 | Academia Cantolao | 10:00 |
| Sport Huancayo | 4 - 3 | U. San Martin | 13:00 |
| Universitario | 2 - 0 | Atletico Grau | 15:30 |
| Sport Boys | 1 - 1 | Deportivo Municipal | 18:00 |
